Photo from wikipedia
Receptor–Blocking Autoantibodies During Pregnancy Background: Graves disease is an autoimmune disease caused by thyroid-stimulating hormone receptor antibodies (TSH-R-Ab), which can be stimulating (TSAb), neutral, or blocking (TBAb). The net antibody… Click to show full abstract
Receptor–Blocking Autoantibodies During Pregnancy Background: Graves disease is an autoimmune disease caused by thyroid-stimulating hormone receptor antibodies (TSH-R-Ab), which can be stimulating (TSAb), neutral, or blocking (TBAb). The net antibody activity determines the clinical phenotype. Typically, TSAbs dominate, resulting in hyperthyroidism. Rarely, TBAbs prevail, resulting in hypothyroidism (1). The conventional TSH-R-Ab binding assay used in clinical practice does not differentiate among antibody types.
Journal Title: Annals of Internal Medicine
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!