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What is the problem and what is known about it so far? Tenofovir is an important component of the antiretroviral therapy (ART) recommended for the treatment of HIV, and it… Click to show full abstract
What is the problem and what is known about it so far? Tenofovir is an important component of the antiretroviral therapy (ART) recommended for the treatment of HIV, and it comes in different preparations. Tenofovir disoproxil fumarate (TDF) has been found to be associated with a kidney condition called proximal renal tubulopathy and with loss of bone mineral density. Tenofovir alafenamide (TAF) does not have these issues, and most guidelines recommend replacing TDF with TAF. However, TAF is associated with rising blood lipid levels and weight gain in studies of patients newly starting a therapy that includes TAF. For this reason, TAF is not part of the World Health Organization's preferred first-line regimens.
Journal Title: Annals of Internal Medicine
Year Published: 2021
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