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PC945, a novel inhaled azole for treatment of fungal tracheobronchitis post-lung transplantation: a case report

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The median incidence of Aspergillus infections in lung transplant recipients has been reported in up to 20%. The commonest site for infection is the tracheobronchial area, most commonly at the… Click to show full abstract

The median incidence of Aspergillus infections in lung transplant recipients has been reported in up to 20%. The commonest site for infection is the tracheobronchial area, most commonly at the anastomotic site which is particularly vulnerable due to blood supply disruption to the donor airway and the presence of the sutures, a point of adhesion for pathogens. Bronchial anastomotic infections are a major risk factor for dehiscence, bronchial stenosis, fistulas and granulation tissue, with the potential of limiting the lung capacity and facilitate secretion retention.

Keywords: lung; inhaled azole; azole treatment; novel inhaled; treatment fungal; pc945 novel

Journal Title: F1000Research
Year Published: 2019

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