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Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined.… Click to show full abstract
Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury and disease.
Keywords:
reporter mice;
class;
mhc class;
immune oligodendroglia
Journal Title: eLife
Year Published: 2022
Link to full text (if available)
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Journal Title: eLife
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!