LAUSR

BACKGROUND Abnormal serum lipids are closely related to cardiovascular disease. Recent studies have shown that vitamin D (VD) and vitamin D receptor (VDR) FokI polymorphism as well as dietary pattern are involved in regulating serum lipids. METHODS According to diet pattern, adolescents were divided into high-carbohydrate (high-CHO) and non-high-carbohydrate (non-high-CHO) diet group. Based on VDR FokI polymorphism, they were assigned into TT genotype and C allele carriers. Serum lipids, glucose, and 25-hydroxyvitamin D [25(OH)D] were measured. A linear regression model was established and analyzed. RESULTS Subjects in the non-high-CHO diet group had higher glucose than those in the high-CHO diet group. With the increasing of VD, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), cholesterol/high density lipoprotein cholesterol (TC/HDL-C), LDL-C/HDL-C decreased. TT genotype subjects had higher TC and HDL-C compared with C allele carriers. As for log triglycerides (TG), TC/HDL-C, logTG/HDL-C, there were interactions between the level of VD and diet pattern. Under the low VD level, subjects in the high-CHO diet group had higher logTG and logTG/HDL-C compared with those in the non-high-CHO diet group. However, under the medium and high level of VD, the results were opposite. In addition, under the low and medium level of VD, subjects in the high-CHO diet group had higher TC/HDL-C. CONCLUSIONS Serum lipids are not only affected by vitamin D, VDR FokI polymorphism and dietary pattern, but also interrelated as well. The impact of diet pattern on lipids may be reversed by the high level of serum VD.