Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients
Sign Up to like & getrecommendations! Published in 2022 at "Cell"
DOI: 10.1016/j.cell.2022.01.003
Abstract: Metastatic progression is the main cause of death in cancer patients, whereas the underlying genomic mechanisms driving metastasis remain largely unknown. Here, we assembled MSK-MET, a pan-cancer cohort of over 25,000 patients with metastatic diseases.… read more here.
Keywords: cancer; genomic characterization; metastatic patterns; 000 patients ... See more keywords
COVID-19 in Brazil
Sign Up to like & getrecommendations! Published in 2020 at "Pulmonology"
DOI: 10.1016/j.pulmoe.2020.04.008
Abstract: It has been ∼4 months since the first case of coronavirus disease 2019 (COVID-19) was reported in Wuhan, China including a total of ∼82,000 patients and 3,341 deaths. Until April 14, 2020, COVID-19 has affected… read more here.
Keywords: 000 patients; 000 deaths; patients 000; covid ... See more keywords
Mutational Landscape of Metastatic Cancer Revealed from Prospective Clinical Sequencing of 10,000 Patients
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DOI: 10.1038/nm.4333
Abstract: Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically defined… read more here.
Keywords: tumor types; clinical sequencing; 000 patients; cancer ... See more keywords
Small studies in systematic reviews: To include or not to include?
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DOI: 10.12688/f1000research.127100.1
Abstract: Background: COVID-19 provided a real challenge for evidence synthesis due to the rapid growth of evidence. We aim to assess the impact of including all studies versus including larger studies only in systematic reviews when… read more here.
Keywords: small studies; systematic reviews; 000 patients; evidence ... See more keywords