Is continuous infusion of imipenem always the best choice?
Sign Up to like & getrecommendations! Published in 2017 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2016.12.005
Abstract: Monte Carlo simulations allow prediction and comparison of concentration-time profiles arising from different dosing regimens in a defined population, provided a population pharmacokinetic model has been established. The aims of this study were to evaluate… read more here.
Keywords: 100 mic; continuous infusion; infusion; infusion imipenem ... See more keywords
Therapeutic drug monitoring of &bgr;-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dky314
Abstract: Objectives To describe the achievement of unbound β-lactam antibiotic concentration targets in a therapeutic drug monitoring (TDM) programme in critically ill patients, and the factors associated with failure to achieve a target concentration. Patients and… read more here.
Keywords: 100 mic; drug; therapeutic drug; critically ill ... See more keywords
Population Pharmacokinetics and Dosing Optimization of Ceftazidime in Term Asphyxiated Neonates during Controlled Therapeutic Hypothermia
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DOI: 10.1128/aac.01707-22
Abstract: Ceftazidime is an antibiotic commonly used to treat bacterial infections in term neonates undergoing controlled therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy after perinatal asphyxia. We aimed to describe the population pharmacokinetics (PK) of ceftazidime in… read more here.
Keywords: 100 mic; population pharmacokinetics; therapeutic hypothermia; population ... See more keywords
Population Pharmacokinetics and Probability of Target Attainment of Different Dosing Regimens of Ceftazidime in Critically Ill Patients with a Proven or Suspected Pseudomonas aeruginosa Infection
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DOI: 10.3390/antibiotics10060612
Abstract: Altered pharmacokinetics (PK) of hydrophilic antibiotics in critically ill patients is common, with possible consequences for efficacy and resistance. We aimed to describe ceftazidime population PK in critically ill patients with a proven or suspected… read more here.
Keywords: 100 mic; ill patients; critically ill; patients proven ... See more keywords