Articles with "1017 esmethadone" as a keyword



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REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats

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Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.863959

Abstract: REL-1017 (esmethadone; dextromethadone; (S)-methadone) is the opioid-inactive dextro-isomer of the racemic mixture, (R, S)-methadone. REL-1017 acts as a low affinity, low potency N-methyl-D-aspartate receptor (NMDAR) channel blocker with rapid, robust, and sustained therapeutic effects in… read more here.

Keywords: sprague dawley; rel 1017; 1017 esmethadone; rel ... See more keywords