Articles with "110 fluorometric" as a keyword



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Novel Imidazole Phenoxyacetic Acids as Inhibitors of USP30 for Neuroprotection Implication via the Ubiquitin-Rho-110 Fluorometric Assay: Design, Synthesis, and In Silico and Biochemical Assays.

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Published in 2022 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.2c00076

Abstract: USP30, a deubiquitinating enzyme family, forfeits the ubiquitination of E3 ligase and Parkin on the surface of mitochondria. Inhibition of USP30 results in mitophagy and cellular clearance. Herein, by understanding structural requirements, we discovered potential… read more here.

Keywords: synthesis; novel imidazole; fluorometric assay; 110 fluorometric ... See more keywords