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Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00076
Abstract: USP30, a deubiquitinating enzyme family, forfeits the ubiquitination of E3 ligase and Parkin on the surface of mitochondria. Inhibition of USP30 results in mitophagy and cellular clearance. Herein, by understanding structural requirements, we discovered potential…
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Keywords:
synthesis;
novel imidazole;
fluorometric assay;
110 fluorometric ... See more keywords