Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects
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DOI: 10.1002/cpt.2052
Abstract: The antiemetic and gastroprokinetic drug metoclopramide is a weak substrate of the blood‐brain barrier (BBB) efflux transporter P‐gp and displays central nervous system (CNS) side effects (i.e., extrapyramidal symptoms and tardive dyskinesia) caused by dopamine… read more here.
Keywords: elderly subjects; 11c metoclopramide; clearance; brain ... See more keywords
Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [11C]Metoclopramide in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical research"
DOI: 10.1007/s11095-021-03002-2
Abstract: PURPOSE To investigate the role of cation transporters (OCTs, MATEs) in the renal and hepatic disposition of the radiolabeled antiemetic drug [11C]metoclopramide in mice with PET. METHODS PET was performed in wild-type mice after administration… read more here.
Keywords: 11c metoclopramide; metoclopramide mice; metoclopramide; cation transporters ... See more keywords