Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.09.018
Abstract: Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests a role for neuroinflammation, no study has directly provided evidence of brain glial activation… read more here.
Keywords: glial activation; signal; brain; 11c pbr28 ... See more keywords
Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [11C]PBR28 study
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2017.08.063
Abstract: Patients with schizophrenia show whole brain and cortical gray matter (GM) volume reductions which are progressive early in their illness. Microglia, the resident immune cells in the CNS, phagocytose neurons and synapses. Some post mortem… read more here.
Keywords: volume; gray matter; matter volume; 11c pbr28 ... See more keywords
Neuroinflammation in Huntington's Disease: New Insights with 11C-PBR28 PET/MRI.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00072
Abstract: Huntington's disease is a devastating neurodegenerative genetic disorder that causes progressive motor dysfunction, emotional disturbances, and cognitive impairment. Unfortunately, there is no treatment to cure or slow the progression of the disease. Neuroinflammation is one… read more here.
Keywords: pet; huntington disease; huntington; neuroinflammation ... See more keywords
18F-PBR06 Versus 11C-PBR28 PET for Assessing White Matter Translocator Protein Binding in Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000002179
Abstract: Background and Purpose 18F-PBR06 and 11C-PBR28 are second-generation PET radioligands targeting the 18-kd translocator protein to assess microglial activation. We directly compared 18F-PBR06 and 11C-PBR28 for detecting brain translocator protein binding in multiple sclerosis (MS).… read more here.
Keywords: translocator protein; 11c pbr28; 18f pbr06; pet ... See more keywords
Quantification of [11C]PBR28 data after systemic lipopolysaccharide challenge
Sign Up to like & getrecommendations! Published in 2020 at "EJNMMI Research"
DOI: 10.1186/s13550-020-0605-7
Abstract: Lipopolysaccharide (LPS) is a classic immune stimulus. LPS combined with positron emission tomography (PET) 18 kDa translocator protein (TSPO) brain imaging provides a robust human laboratory model to study neuroimmune signaling. To evaluate optimal analysis of… read more here.
Keywords: challenge quantification; quantification; 11c pbr28; pbr28 data ... See more keywords
Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia
Sign Up to like & getrecommendations! Published in 2021 at "Neurology"
DOI: 10.1212/wnl.0000000000011612
Abstract: Objective To examine whether early β–amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia. Methods We examined 54 volunteers (mean age 70.0 years, 56% women, 51% APOE ɛ4… read more here.
Keywords: early amyloid; amyloid accumulation; 11c pbr28; neuroinflammation ... See more keywords