Further in vivo characterization of [11C]‐(+)‐PHNO uptake into a retina‐like region of interest in humans
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DOI: 10.1002/syn.22135
Abstract: The neurotransmitter dopamine is present in the retina and is involved in several modulatory functions. Unlike in rodents, dopamine D3 receptors are expressed in the retina of humans. Recently, uptake of the D3 receptor‐preferring radiotracer… read more here.
Keywords: retina like; region interest; 11c phno; like region ... See more keywords
Binding of the D3-preferring antipsychotic candidate F17464 to dopamine D3 and D2 receptors: a PET study in healthy subjects with [11C]-(+)-PHNO
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DOI: 10.1007/s00213-019-05387-w
Abstract: F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial… read more here.
Keywords: receptor occupancy; study healthy; 11c phno; f17464 dopamine ... See more keywords
Separating dopamine D2 and D3 receptor sources of [11C]-(+)-PHNO binding potential: Independent component analysis of competitive binding
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DOI: 10.1016/j.neuroimage.2020.116762
Abstract: Development of medications selective for dopamine D2 or D3 receptors is an active area of research in numerous neuropsychiatric disorders including addiction and Parkinson's disease. The positron emission tomography (PET) radiotracer [11C]-(+)-PHNO, an agonist that… read more here.
Keywords: independent component; phno binding; 11c phno; receptor ... See more keywords
Association of dopamine D2/3 receptor binding potential measured using PET and [11C]-(+)-PHNO with post-mortem DRD2/3 gene expression in the human brain
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DOI: 10.1016/j.neuroimage.2020.117270
Abstract: Open access post mortem transcriptome atlases such as the Allen Human Brain Atlas (AHBA) can inform us about mRNA expression of numerous proteins of interest across the whole brain, while in vivo protein binding in… read more here.
Keywords: 11c phno; expression; mrna expression; human brain ... See more keywords
Occupancy of dopamine D2 and D3 receptors by a novel D3 partial agonist BP1.4979: a [11C]-(+)-PHNO PET study in humans
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DOI: 10.1038/s41386-018-0285-4
Abstract: There has been considerable interest in the development of dopamine D3 receptor (DRD3) partial agonists and antagonists for the treatment of substance use disorders. Pre-clinical evidence overwhelmingly supports the use of these drugs, but translation… read more here.
Keywords: novel partial; bp1; bp1 4979; agonist bp1 ... See more keywords
Motor Synchronization to Rhythmic Auditory Stimulation (RAS) Attenuates Dopaminergic Responses in Ventral Striatum in Young Healthy Adults: [11C]-(+)-PHNO PET Study
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DOI: 10.3389/fnins.2019.00106
Abstract: Auditory-motor entrainment using rhythmic auditory stimulation (RAS) has been shown to improve motor control in healthy persons and persons with neurologic motor disorders such as Parkinson’s disease and stroke. Neuroimaging studies have shown the modulation… read more here.
Keywords: phno pet; rhythmic auditory; auditory stimulation; 11c phno ... See more keywords