Enhanced diagnostic and prognostic assessment of cardiac amyloidosis using combined 11C-PiB PET/CT and 99mTc-DPD scintigraphy
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-025-07157-7
Abstract: Cardiac amyloidosis (CA) is a severe condition characterized by amyloid fibril deposition in the myocardium, leading to restrictive cardiomyopathy and heart failure. Differentiating between amyloidosis subtypes is crucial due to distinct treatment strategies. The individual… read more here.
Keywords: dpd scintigraphy; amyloidosis; 99mtc dpd; pet 99mtc ... See more keywords
Significance of 11C-PIB PET/CT in cardiac amyloidosis compared with 99mTc-aprotinin scintigraphy: A pilot study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nuclear Cardiology"
DOI: 10.1007/s12350-018-1260-5
Abstract: AbstractBackgroundThis study was to investigate the significance of 11C-Pittsburgh B (PIB) PET/CT in patients with suspected cardiac amyloidosis compared with 99mTc-aprotinin scintigraphy. MethodsThirteen consecutive patients with suspected cardiac amyloidosis were considered for enrolment in this… read more here.
Keywords: 99mtc aprotinin; study; 11c pib; amyloidosis ... See more keywords
Brain amyloid PET interpretation approaches: from visual assessment in the clinic to quantitative pharmacokinetic modeling
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DOI: 10.1007/s40336-017-0257-4
Abstract: PurposeCerebral β-amyloid burden can be measured by positron emission tomography (PET) tracers, including 11C-Pittsburgh Compound B (11C-PiB) and three fluorinated tracers that have been approved by regulatory agencies. This review focuses on the current clinical… read more here.
Keywords: pharmacokinetic modeling; interpretation; 11c pib; amyloid pet ... See more keywords
Myelin imaging measures as predictors of cognitive impairment in MS patients: A hybrid PET-MRI study.
Sign Up to like & getrecommendations! Published in 2022 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2021.103331
Abstract: BACKGROUND Cognitive impairment is one of the concerns of Multiple Sclerosis (MS) and has been related to myelin loss. Different neuroimaging methods have been used to quantify myelin and relate it to cognitive dysfunctions, among… read more here.
Keywords: 11c pib; predictors cognitive; mtr; myelin imaging ... See more keywords
Comparison of longitudinal Aβ in nondemented elderly and Down syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.09.030
Abstract: Down syndrome (DS) predisposes individuals to early Alzheimer's disease (AD). Using Pittsburgh Compound B ([11C]PiB), a pattern of striatal amyloid beta (Aβ) that is elevated relative to neocortical binding has been reported, similar to that… read more here.
Keywords: nondemented elderly; compared nde; time; 11c pib ... See more keywords
Head-to-head comparison of 11C-PiB and 18F-FC119S for Aβ imaging in healthy subjects, mild cognitive impairment patients, and Alzheimer's disease patients
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DOI: 10.1097/md.0000000000006441
Abstract: Abstract As a new beta amyloid (A&bgr;) positron emission tomography (PET) tracer, 18F-FC119S has shown higher cortical uptake in patients with Alzheimer's disease (AD) than that in healthy control subjects without adverse effects in a… read more here.
Keywords: 11c pib; 18f fc119s; fc119s pet;
A 5-year longitudinal evaluation in patients with mild cognitive impairment by 11C-PIB PET/CT: a visual analysis
Sign Up to like & getrecommendations! Published in 2019 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001004
Abstract: Objective The aim of this study was to evaluate the cerebral amyloid distribution in patients with mild cognitive impairment (MCI), assessed by carbon-11-Pittsburgh compound B (11C-PIB) PET/CT, after 5 years of follow-up. Patients and methods… read more here.
Keywords: 11c pib; pib pet; pib retention; pib ... See more keywords
Visual assessments of 11C-Pittsburgh compound-B PET vs. 18F-flutemetamol PET across the age spectrum
Sign Up to like & getrecommendations! Published in 2024 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001902
Abstract: Objective Visual assessments of amyloid-β PET, used for Alzheimer’s disease (AD) diagnosis and treatment evaluation, require a careful approach when different PET ligands are utilized. Because the gray matter (GM) and white matter (WM) ligand… read more here.
Keywords: pet 18f; flutemetamol pet; 18f flutemetamol; pib pet ... See more keywords
Depression modifies age-associated [11C]PiB-PET amyloid burden in a cohort enriched with risk for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Alzheimer's Disease"
DOI: 10.1177/13872877251353098
Abstract: Background Depression—especially late-life onset—is associated with age-related cognitive decline and may be a key risk factor for amyloid-β (Aβ) deposition in preclinical Alzheimer's disease (AD). Objective This study assesses whether depressive symptoms modify the relationship… read more here.
Keywords: age; alzheimer disease; gds; risk ... See more keywords
Can 11C-PiB-PET Relative Delivery R1 or 11C-PiB-PET Perfusion Replace 18F-FDG-PET in the Assessment of Brain Neurodegeneration?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-180274
Abstract: Background: Pittsburgh Compound B (PiB) positron emission tomography (PET) is used to visualize in vivo amyloid plaques in the brain. Frequently the PiB examinations are complemented with a fluorodeoxyglucose (FDG) PET scan to further assess… read more here.
Keywords: pib; fdg pet; 11c pib; neurodegeneration ... See more keywords
An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.847074
Abstract: Positron emission tomography (PET) has become an essential clinical tool for diagnosing neurodegenerative diseases with abnormal accumulation of proteins like amyloid-β or tau. Despite many attempts, it has not been possible to develop an appropriate… read more here.
Keywords: positron emission; brain; 11c pib; pig model ... See more keywords