Synthesis and Preclinical Positron Emission Tomography Imaging of the p38 MAPK Inhibitor [11C]Talmapimod: Effects of Drug Efflux and Sex Differences.
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DOI: 10.1021/acschemneuro.3c00205
Abstract: Stress-activated kinases are targets of interest in neurodegenerative disease due to their involvement in inflammatory signaling and synaptic dysfunction. The p38α kinase has shown clinical and preclinical promise as a druggable target in several neurodegenerative… read more here.
Keywords: 11c talmapimod; brain; inhibitor; sex ... See more keywords