Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4119-8
Abstract: PurposeA [11C]UCB-J blocking study was performed in healthy volunteers to validate simplified, non-invasive measures for quantifying presynaptic SV2A expression using subcortical white matter as reference tissue.MethodsNinety minutes dynamic [11C]UCB-J PET scanning with arterial blood sampling… read more here.
Keywords: reference tissue; suvrso 90min; reference; 11c ucb ... See more keywords
Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis
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DOI: 10.1016/j.neuroimage.2021.118167
Abstract: Background: The human brain is inherently organized into distinct networks, as reported widely by resting-state functional magnetic resonance imaging (rs-fMRI), which are based on blood-oxygen-level-dependent (BOLD) signal fluctuations. 11C-UCB-J PET maps synaptic density via synaptic… read more here.
Keywords: source networks; brain; synaptic density; 11c ucb ... See more keywords
Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer’s disease
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DOI: 10.1016/j.neuroimage.2021.118248
Abstract: Purpose: 11C-UCB-J PET imaging, targeting synaptic vesicle glycoprotein 2A (SV2A), has been shown to be a useful indicator of synaptic density in Alzheimer’s disease (AD). For SV2A imaging, a decrease in apparent tracer uptake is… read more here.
Keywords: volume; alzheimer disease; ucb pet; correction ... See more keywords