Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma
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DOI: 10.3389/fonc.2022.929123
Abstract: Neuroblastoma is the most common extracranial solid tumor found in children and despite intense multi-modal therapeutic approaches, low overall survival rates of high-risk patients persist. Tumors with heterozygous loss of chromosome 11q and MYCN amplification… read more here.
Keywords: chromosome 11q; checkpoint kinase; loss; 11q loss ... See more keywords