PrP (122-139) is a covert mitochondrial targeting signal of prion protein and it specifically triggers the perinuclear clustering of mitochondria in neuronal culture cells.
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DOI: 10.1016/j.bbrc.2020.01.099
Abstract: In many neurodegenerative diseases, mitochondria are actively involved in the onset and/or progression of diseases because the energy depletion of the neuronal cells directly leads to the dysfunction and degeneration of cells. In the case… read more here.
Keywords: 122 139; prion; mitochondrial targeting; prion protein ... See more keywords