Leptin suppresses microRNA‐122 promoter activity by phosphorylation of foxO1 in hepatic stellate cell contributing to leptin promotion of mouse liver fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.12.007
Abstract: &NA; Adipocytokine leptin promotes hepatic stellate cell (HSC) activation (a key step in liver fibrogenesis) and liver fibrosis. microRNA‐122 (miR‐122) is the most abundant liver‐specific miRNA and was demonstrated to inhibit liver fibrosis and reduced… read more here.
Keywords: liver fibrosis; 122 promoter; leptin; foxo1 ... See more keywords