Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease
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DOI: 10.1016/j.ejphar.2017.12.006
Abstract: ABSTRACT The purinergic receptor P2X ligand‐gated ion channel 7 (P2X7 receptor) is a promising imaging target to detect neuroinflammation. Herein, we report development of a potent iodinated radiotracer for P2X7 receptor, [123I]TZ6019. The radiosynthesis of… read more here.
Keywords: receptor; p2x7 receptor; 123i tz6019; neuroinflammation ... See more keywords