Synthesis of 12b‐methyl‐isoindoloisoquinolin‐8‐ones via Iridium‐Catalyzed Intramolecular Hydroarylation of Phenacyl Enamides
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DOI: 10.1002/ejoc.202500451
Abstract: We describe an intramolecular iridium‐catalyzed hydroarylation process for the synthesis of the title scaffold from phenacyl enamide substrates. This method achieves high yields while eliminating the requirement for pre‐functionalized substrates, as compared to Heck‐type cyclization… read more here.
Keywords: iridium; iridium catalyzed; 12b methyl; hydroarylation ... See more keywords