Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13C‐isotopomers derived from [U‐13C]fructose and [U‐13C]glucose
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DOI: 10.1002/mrm.28286
Abstract: The pentose phosphate pathway (PPP) is an important component of hepatic intermediary metabolism. Jin et al developed an elegant 13C‐NMR method for measuring hepatic PPP flux by quantifying the distribution of glucose 13C‐isotopomers formed from… read more here.
Keywords: phosphate pathway; fructose 13c; pentose phosphate; 13c isotopomers ... See more keywords
13C-glucose breath tests: a non-invasive method for detecting early clinical manifestations of exogenous glucose metabolism in type 2 diabetic patients
Sign Up to like & getrecommendations! Published in 2018 at "Acta Diabetologica"
DOI: 10.1007/s00592-018-1276-y
Abstract: Aims13C-glucose breath tests are reported as an alternative non-invasive method to evaluate glucose metabolism. However, the metabolic results differ based on the site of the carbon atom in the glucose. The aim of this study… read more here.
Keywords: breath tests; breath; diabetic patients; glucose metabolism ... See more keywords
Accuracy of the 13C-glucose breath test to identify insulin resistance in non-diabetic adults
Sign Up to like & getrecommendations! Published in 2019 at "Acta Diabetologica"
DOI: 10.1007/s00592-019-01318-5
Abstract: AimsTo assess the validity of the 13C-glucose breath test (13C-GBT) to identify insulin resistance (IR) in non-diabetic individuals, using hyperinsulinemic–euglycemic clamps as gold standard. This validity was compared with that of other IR surrogates.MethodologyNon-diabetic adults… read more here.
Keywords: insulin; diabetic adults; gbt; 13c glucose ... See more keywords
Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
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DOI: 10.1038/s41598-021-85339-7
Abstract: Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is… read more here.
Keywords: glioblastoma; aerobic glycolysis; gbm; magnetic resonance ... See more keywords
Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake mediated by multiple transporters
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DOI: 10.1042/bcj20190504
Abstract: Coxiella burnetii is a Gram-negative bacterium which causes Q fever, a complex and life-threatening infection with both acute and chronic presentations. C. burnetii invades a variety of host cell types and replicates within a unique… read more here.
Keywords: burnetii utilizes; infection; coxiella burnetii; burnetii ... See more keywords
Combined HP 13C Pyruvate and 13C-Glucose Fluxomic as a Potential Marker of Response to Targeted Therapies in YUMM1.7 Melanoma Xenografts
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10030717
Abstract: A vast majority of BRAF V600E mutated melanoma patients will develop resistance to combined BRAF/MEK inhibition after initial clinical response. Resistance to targeted therapy is described to be accompanied by specific metabolic changes in melanoma.… read more here.
Keywords: 13c glucose; mek inhibition; marker response; response ... See more keywords
Serum Starvation Accelerates Intracellular Metabolism in Endothelial Cells
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DOI: 10.3390/ijms24021189
Abstract: Periods of low energy supply are challenging conditions for organisms and cells during fasting or famine. Although changes in nutrient levels in the blood are first sensed by endothelial cells, studies on their metabolic adaptations… read more here.
Keywords: 13c glucose; endothelial cells; glucose 13c; serum starvation ... See more keywords