Rapid Evaluation of the Mechanism of Buchwald-Hartwig Amination and Aldol Reactions Using Intramolecular 13C Kinetic Isotope Effects.
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DOI: 10.1021/acscatal.0c04752
Abstract: A practical approach is introduced for the rapid determination of 13C kinetic isotope effects that utilizes a "designed" reactant with two identical reaction sites. The mechanism of the Buchwald-Hartwig amination of tert-butylbromobenzene with primary and… read more here.
Keywords: 13c kinetic; hartwig amination; methodology; mechanism ... See more keywords