Metabolic Tumor Imaging with Rapidly Signal‐Enhanced 1‐13C‐Pyruvate‐d3
Sign Up to like & getrecommendations! Published in 2022 at "Chemphyschem"
DOI: 10.1002/cphc.202200615
Abstract: Abstract The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is possible to perform metabolic imaging to reveal not only the exact location of a tumor, but also intratumoral… read more here.
Keywords: signal enhanced; pyruvate; metabolic tumor; 13c pyruvate ... See more keywords
Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13C,15N2]urea + [1‐13C]pyruvate simultaneous perfusion and metabolic imaging
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29266
Abstract: This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack‐of‐spiral balanced steady‐state free precession(3D‐bSSFP) urea sequence, interleaved with a metabolite‐specific gradient echo (GRE) sequence for pyruvate and metabolic products, for… read more here.
Keywords: magnetic resonance; hyperpolarized 13c; 15n2 urea; 13c 15n2 ... See more keywords
Model‐constrained reconstruction accelerated with Fourier‐based undersampling for hyperpolarized [1‐13C] pyruvate imaging
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29551
Abstract: Model‐constrained reconstruction with Fourier‐based undersampling (MoReFUn) is introduced to accelerate the acquisition of dynamic MRI using hyperpolarized [1‐13C]‐pyruvate. read more here.
Keywords: fourier based; model constrained; hyperpolarized 13c; constrained reconstruction ... See more keywords
A pharmacokinetic model for hyperpolarized 13C‐pyruvate MRI when using metabolite‐specific bSSFP sequences
Sign Up to like & getrecommendations! Published in 2024 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.30142
Abstract: Metabolite‐specific balanced SSFP (MS‐bSSFP) sequences are increasingly used in hyperpolarized [1‐13C]Pyruvate (HP 13C) MRI studies as they improve SNR by refocusing the magnetization each TR. Currently, pharmacokinetic models used to fit conversion rate constants, kPL… read more here.
Keywords: metabolite specific; mri; hyperpolarized 13c; bssfp sequences ... See more keywords
Increasing Infusion Times of Hyperpolarized [1-13C]Pyruvate in a Mouse Brain Maintain Lactate Generation and Approach Pseudo-Steady State Metabolism.
Sign Up to like & getrecommendations! Published in 2025 at "Magnetic resonance in medicine"
DOI: 10.1002/mrm.70175
Abstract: PURPOSE To investigate whether varying delivery times of hyperpolarized [1-13C]pyruvate, enabled by the increased apparent T1 dissolved in deuterium oxide (D2O), affects the observed kinetics of glycolytic brain metabolism in vivo. METHODS Eighteen healthy mice… read more here.
Keywords: hyperpolarized 13c; times hyperpolarized; metabolism; 13c pyruvate ... See more keywords
Brain metabolism under different anesthetic conditions using hyperpolarized [1‐13C]pyruvate and [2‐13C]pyruvate
Sign Up to like & getrecommendations! Published in 2018 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4012
Abstract: Carbon‐13 NMR spectroscopy (13C MRS) offers the unique capability to measure brain metabolic rates in vivo. Hyperpolarized 13C reduces the time required to assess brain metabolism from hours to minutes when compared with conventional 13C… read more here.
Keywords: anesthetic conditions; pyruvate; metabolism; 13c pyruvate ... See more keywords
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1‐13C]pyruvate
Sign Up to like & getrecommendations! Published in 2020 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4250
Abstract: Hyperpolarised [1‐13C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus‐1… read more here.
Keywords: glioma; pyruvate; gene therapy; 13c pyruvate ... See more keywords
Tracking Hyperpolarized [1‐13C] Pyruvate and [1‐13C] L‐Lactate Metabolism in the Healthy and Post‐Stroke Mouse Brain
Sign Up to like & getrecommendations! Published in 2025 at "Nmr in Biomedicine"
DOI: 10.1002/nbm.70094
Abstract: Tracking hyperpolarized (HP) 13C labeling from either [1‐13C] pyruvate or [1‐13C] lactate is a useful tool to assess intermediary metabolism in vivo, which has already been translated from preclinical to clinical research. HP [1‐13C] pyruvate… read more here.
Keywords: pyruvate 13c; 13c lactate; 13c pyruvate; metabolism ... See more keywords
Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c01715
Abstract: Despite great successes in oncology, patient outcomes are often still discouraging, and hence the diagnostic imaging paradigm is increasingly shifting toward functional imaging of the pathology to better understand individual disease biology and to personalize… read more here.
Keywords: dissolution signal; signal amplification; hyperpolarized 13c; pyruvate ... See more keywords
Comparative Evaluation of Hyperpolarized [13C]pyruvate and [13C]lactate for Imaging Neuronal and Glioma Metabolism.
Sign Up to like & getrecommendations! Published in 2025 at "ACS sensors"
DOI: 10.1021/acssensors.5c03203
Abstract: Glucose and lactate are primary substrates in cerebral energy metabolism. Hyperpolarized [1-13C]pyruvate has become a powerful imaging agent for metabolic neuroimaging due to its central role in glucose and lactate metabolism, ability to cross the… read more here.
Keywords: 13c lactate; hyperpolarized 13c; metabolism; 13c pyruvate ... See more keywords
Real-time ex-vivo measurement of brain metabolism using hyperpolarized [1-13C]pyruvate
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27747-w
Abstract: The ability to directly monitor in vivo brain metabolism in real time in a matter of seconds using the dissolution dynamic nuclear polarization technology holds promise to aid the understanding of brain physiology in health… read more here.
Keywords: real time; metabolism; 13c pyruvate; hyperpolarized 13c ... See more keywords