Metabolic Tumor Imaging with Rapidly Signal‐Enhanced 1‐13C‐Pyruvate‐d3
Sign Up to like & getrecommendations! Published in 2022 at "Chemphyschem"
DOI: 10.1002/cphc.202200615
Abstract: Abstract The metabolism of malignant cells differs significantly from that of healthy cells and thus, it is possible to perform metabolic imaging to reveal not only the exact location of a tumor, but also intratumoral… read more here.
Keywords: signal enhanced; pyruvate; metabolic tumor; 13c pyruvate ... See more keywords
Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13C,15N2]urea + [1‐13C]pyruvate simultaneous perfusion and metabolic imaging
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29266
Abstract: This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack‐of‐spiral balanced steady‐state free precession(3D‐bSSFP) urea sequence, interleaved with a metabolite‐specific gradient echo (GRE) sequence for pyruvate and metabolic products, for… read more here.
Keywords: magnetic resonance; hyperpolarized 13c; 15n2 urea; 13c 15n2 ... See more keywords
Model‐constrained reconstruction accelerated with Fourier‐based undersampling for hyperpolarized [1‐13C] pyruvate imaging
Sign Up to like & getrecommendations! Published in 2022 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.29551
Abstract: Model‐constrained reconstruction with Fourier‐based undersampling (MoReFUn) is introduced to accelerate the acquisition of dynamic MRI using hyperpolarized [1‐13C]‐pyruvate. read more here.
Keywords: fourier based; model constrained; hyperpolarized 13c; constrained reconstruction ... See more keywords
Brain metabolism under different anesthetic conditions using hyperpolarized [1‐13C]pyruvate and [2‐13C]pyruvate
Sign Up to like & getrecommendations! Published in 2018 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4012
Abstract: Carbon‐13 NMR spectroscopy (13C MRS) offers the unique capability to measure brain metabolic rates in vivo. Hyperpolarized 13C reduces the time required to assess brain metabolism from hours to minutes when compared with conventional 13C… read more here.
Keywords: anesthetic conditions; pyruvate; metabolism; 13c pyruvate ... See more keywords
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1‐13C]pyruvate
Sign Up to like & getrecommendations! Published in 2020 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4250
Abstract: Hyperpolarised [1‐13C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus‐1… read more here.
Keywords: glioma; pyruvate; gene therapy; 13c pyruvate ... See more keywords
Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c01715
Abstract: Despite great successes in oncology, patient outcomes are often still discouraging, and hence the diagnostic imaging paradigm is increasingly shifting toward functional imaging of the pathology to better understand individual disease biology and to personalize… read more here.
Keywords: dissolution signal; signal amplification; hyperpolarized 13c; pyruvate ... See more keywords
Real-time ex-vivo measurement of brain metabolism using hyperpolarized [1-13C]pyruvate
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27747-w
Abstract: The ability to directly monitor in vivo brain metabolism in real time in a matter of seconds using the dissolution dynamic nuclear polarization technology holds promise to aid the understanding of brain physiology in health… read more here.
Keywords: real time; metabolism; 13c pyruvate; hyperpolarized 13c ... See more keywords
PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85136-2
Abstract: Parahydrogen-induced polarization of 13C nuclei by side-arm hydrogenation (PHIP-SAH) for [1-13C]acetate and [1-13C]pyruvate esters with application of PH-INEPT-type pulse sequences for 1H to 13C polarization transfer is reported, and its efficiency is compared with that… read more here.
Keywords: polarization transfer; 13c pyruvate; polarization; 13c acetate ... See more keywords
[13C]bicarbonate labelled from hyperpolarized [1-13C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state
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DOI: 10.1038/s42003-021-02978-2
Abstract: Hyperpolarized [1- 13 C]pyruvate enables direct in vivo assessment of real-time liver enzymatic activities by 13 C magnetic resonance. However, the technique usually requires the injection of a highly supraphysiological dose of pyruvate. We herein… read more here.
Keywords: hyperpolarized 13c; pyruvate; hepatic gluconeogenesis; state ... See more keywords
CBMT-36. INITIAL EXPERIENCE WITH HYPERPOLARIZED [2-13C]PYRUVATE MR IMAGING IN PATIENTS WITH IDH-MUTANT GLIOMA
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.158
Abstract: Hyperpolarized (HP) carbon-13 MR imaging allows for real-time non-invasive measurement of metabolism. Using HP [2-13C]pyruvate as a molecular probe enables the measurement of both aerobic glycolysis ([2-13C]lactate) and oxidative metabolism (such as [5-13C]glutamate and [5-13C]glutamine).… read more here.
Keywords: pyruvate; 13c pyruvate; idh mutant; glutamate ... See more keywords
Hyperpolarized [1‐13C]pyruvate combined with the hyperinsulinaemic euglycaemic and hypoglycaemic clamp technique in skeletal muscle in a large animal model
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Physiology"
DOI: 10.1113/ep089782
Abstract: What is the central question of this study? Is it possible to combine the hyperpolarized magnetic resonance technique and the hyperinsulinaemic clamp method in order to evaluate skeletal muscle metabolism in a large animal model?… read more here.
Keywords: skeletal muscle; 13c pyruvate; large animal; technique ... See more keywords