A novel, topical, nonsteroidal, TRPV1 antagonist, PAC-14028 cream improves skin barrier function and exerts anti-inflammatory action through modulating epidermal differentiation markers and suppressing Th2 cytokines in atopic dermatitis.
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DOI: 10.1016/j.jdermsci.2018.04.017
Abstract: BACKGROUND Although it is established that epidermal barrier disturbance and immune dysfunction resulting in IgE sensitization are critical factors in the development of cutaneous inflammation, the pathogenesis and targeted therapy of atopic dermatitis (AD)-specific pathways… read more here.
Keywords: barrier; 14028 cream; barrier function; dermatitis ... See more keywords