MicroRNAs-143 and -145 induce epithelial to mesenchymal transition and modulate the expression of junction proteins
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.103
Abstract: Transforming growth factor (TGF)-β is one of the major inducers of epithelial to mesenchymal transition (EMT), a crucial program that has a critical role in promoting carcinoma’s metastasis formation. MicroRNAs-143 and -145, which are both… read more here.
Keywords: epithelial mesenchymal; expression; role; 143 145 ... See more keywords
Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of intracranial aneurysm
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DOI: 10.1038/srep43633
Abstract: MicroRNAs (miRs)-143/145 are involved in various biological processes related to aneurysm formation and are downregulated in patients with intracranial aneurysm (IA). We aimed to determine whether two functional polymorphisms (i.e. rs4705342 and rs4705343) in the… read more here.
Keywords: mir 143; intracranial aneurysm; risk; promoter mir ... See more keywords
Loss of Vascular Myogenic Tone in miR-143/145 Knockout Mice Is Associated With Hypertension-Induced Vascular Lesions in Small Mesenteric Arteries
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DOI: 10.1161/atvbaha.117.310499
Abstract: Objective— Pressure-induced myogenic tone is involved in autoregulation of local blood flow and confers protection against excessive pressure levels in small arteries and capillaries. Myogenic tone is dependent on smooth muscle microRNAs (miRNAs), but the… read more here.
Keywords: mir 143; myogenic tone; tone; knockout mice ... See more keywords
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma
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DOI: 10.15252/emmm.202115295
Abstract: Lineage dedifferentiation toward a mesenchymal‐like state displaying myofibroblast and fibrotic features is a common mechanism of adaptive and acquired resistance to targeted therapy in melanoma. Here, we show that the anti‐fibrotic drug nintedanib is active… read more here.
Keywords: melanoma; mir 143; targeted therapy; pro fibrotic ... See more keywords