The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia
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DOI: 10.1038/s41408-024-01142-3
Abstract: The development and progression of chronic lymphocytic leukemia (CLL) depend on genetic abnormalities and on the immunosuppressive microenvironment. We have explored the possibility that genetic drivers might be responsible for the immune cell dysregulation that… read more here.
Keywords: cluster; 15a mir; microenvironment; dleu2 mir ... See more keywords
Sperm miR‐15a and miR‐29b are associated with bull fertility
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DOI: 10.1111/and.13412
Abstract: MicroRNAs modulate male fertility by regulating gene expression. In this study, dynamics of sperm miR‐15a, miR‐29b and miR‐34a from high fertility (HF) and low fertility (LF) bulls using RT‐qPCR were evaluated. Bioinformatic tools were employed… read more here.
Keywords: 15a mir; bull fertility; mir 15a; fertility ... See more keywords
The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression
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DOI: 10.3389/fimmu.2022.967914
Abstract: Pleiotropic functions of miRNAs as transcriptional repressors have been reported for multiple biological processes. One prominent miRNA family is the miR-15 family, which is a well-established tumor-suppressor in B-cell chronic lymphocytic leukemia (CLL). The miR-15… read more here.
Keywords: cell; mir 15a; 15a mir; mir ... See more keywords