A distinct double positive IL-17A+/F+ T helper 17 cells induced inflammation leads to IL17 producing neutrophils in Type 1 reaction of leprosy patients.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.154873
Abstract: Type 1 reactions (T1R) an inflammatory condition, of local skin patches in 30-40% leprosy patients during the course of MDT. IL-17A and IL-17F play an important role in regulating skin inflammation through neutrophils. In the… read more here.
Keywords: 17a 17f; leprosy patients; double positive; producing neutrophils ... See more keywords
IL-17 in the immunopathogenesis of spondyloarthritis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-018-0044-2
Abstract: Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic arthritis and undifferentiated SpA. The disease subtypes share clinical… read more here.
Keywords: 17a 17f; immunopathology; spondyloarthritis; arthritis ... See more keywords
IL‐17A and IL‐17F polymorphisms and asthma risk: A meta‐analysis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Immunogenetics"
DOI: 10.1111/iji.12616
Abstract: Thank you for your comment on the publication ‘Associations between interleukin 17A and 17F polymorphisms and asthma susceptibility: A meta-analysis’ (Lee & Song, 2023). Your suggestion to focus on the effects of unexpected and potentially… read more here.
Keywords: meta analysis; 17a 17f; 17f polymorphisms; research ... See more keywords
OP0229 GUSELKUMAB INDUCES SUSTAINED REDUCTION IN ACUTE PHASE PROTEINS AND TH17 EFFECTOR CYTOKINES IN ACTIVE PSORIATIC ARTHRITIS IN TWO PHASE-3 CLINICAL TRIALS (DISCOVER-1 AND DISCOVER-2)
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1240
Abstract: Guselkumab (GUS), an IL-23 inhibitor monoclonal antibody (Mab) that specifically binds to the IL-23p19 subunit, demonstrated efficacy compared to placebo (PBO) in reducing skin and musculoskeletal signs and symptoms in patients (pts) with active psoriatic… read more here.
Keywords: janssen research; effector cytokines; 17a 17f; employee janssen ... See more keywords
Guselkumab induces robust reduction in acute phase proteins and type 17 effector cytokines in active psoriatic arthritis: results from phase 3 trials
Sign Up to like & getrecommendations! Published in 2021 at "RMD Open"
DOI: 10.1136/rmdopen-2021-001679
Abstract: Objective To investigate serum protein expression in participants with psoriatic arthritis (PsA) and changes after guselkumab treatment. Methods Participants with PsA were treated with guselkumab or placebo in the DISCOVER-1 and DISCOVER-2 studies. Serum levels… read more here.
Keywords: acute phase; 17a 17f; treatment; effector cytokines ... See more keywords
Dual inhibition of IL-17A and IL-17F in psoriatic disease
Sign Up to like & getrecommendations! Published in 2021 at "Therapeutic Advances in Chronic Disease"
DOI: 10.1177/20406223211037846
Abstract: Psoriasis and psoriatic arthritis are chronic immune-mediated disorders with involvement of interleukin (IL)-17 cytokines in their pathogenesis. IL-17A has been considered to be the most biologically active, but IL-17F is also over-expressed in skin and… read more here.
Keywords: 17a 17f; inhibition 17a; disease; dual inhibition ... See more keywords
Influence of IL10 (rs1800896) Polymorphism and TNF-α, IL-10, IL-17A, and IL-17F Serum Levels in Ankylosing Spondylitis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.653611
Abstract: Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disease that mainly affects the axial and sacroiliac joints. Single-nucleotide polymorphisms (SNPs) in genes encoding cytokines have been associated with AS, which can interfere with the production… read more here.
Keywords: 17a 17f; il10; rs1800896; serum ... See more keywords