Small molecule modulators of IL-17A/IL-17RA: a patent review (2013-2021)
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2143264
Abstract: ABSTRACT Introduction Interleukin-17A (IL-17A) is a well-established pro-inflammatory cytokine, which plays a pivotal role in immune and autoimmune diseases including psoriasis, asthma, psoriatic arthritis, and rheumatoid arthritis. Three currently approved monoclonal antibodies (mAbs) are in… read more here.
Keywords: small molecule; molecule modulators; molecule; 17a 17ra ... See more keywords
The IL-17A/IL-17RA Axis Is Not Related to Overall Survival and Cancer Stem Cell Modulation in Pancreatic Cancer
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DOI: 10.3390/ijms21062215
Abstract: (1) Background: IL-17A accelerates pancreatic intraepithelial neoplasia (PanIN) progression. In this study, we examined whether IL-17A/IL-17RA promotes pancreatic ductal adenocarcinoma (PDAC) aggressiveness in terms of survival and cancer stem cell modulation. (2) Methods: In vitro,… read more here.
Keywords: 17a 17ra; cancer stem; pancreatic cancer; stem cell ... See more keywords