Hyperoside alleviates postmenopausal osteoporosis via regulating miR-19a-5p/IL-17A axis.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of reproductive immunology"
DOI: 10.1111/aji.13709
Abstract: PROBLEM Postmenopausal osteoporosis (PMO) is a common osteoporosis. Hyperoside (Hyp), a natural flavonoid compound, has anti-osteoporotic effects, but the underlying mechanisms remain poorly understood. Inflammatory cytokine IL-17A is upregulated in PMO and plays vital roles… read more here.
Keywords: mir 19a; 19a 17a; pmo; 17a axis ... See more keywords
Host-derived mannose glycans trigger a pathogenic γδ T cell/IL-17a axis in autoimmunity
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abo1930
Abstract: Autoimmune diseases are life-threatening disorders that cause increasing disability over time. Systemic lupus erythematosus (SLE) and other autoimmune diseases arise when immune stimuli override mechanisms of self-tolerance. Accumulating evidence has demonstrated that protein glycosylation is… read more here.
Keywords: glycans trigger; cell; kidney; cell 17a ... See more keywords