Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells
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DOI: 10.1038/s41467-021-27936-8
Abstract: Therapeutic blockade of the immune checkpoint proteins programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA4) has transformed cancer treatment. However, the overall response rate to these treatments is low, suggesting… read more here.
Keywords: cancer; btnl2; tumour; producing cells ... See more keywords
Increased Production of IL-17A-Producing γδ T Cells in the Thymus of Filaggrin-Deficient Mice
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DOI: 10.3389/fimmu.2018.00988
Abstract: Mutations in the filaggrin gene (Flg) are associated with increased systemic levels of Th17 cells and increased IL-17A production following antigen exposure in both humans and mice. In addition to Th17 cells, γδ T cells can produce… read more here.
Keywords: t17 cells; 17a producing; production; filaggrin deficient ... See more keywords