Interleukin 17 regulates SHP‐2 and IL‐17RA/STAT‐3 dependent Cyr61, IL‐23 and GM‐CSF expression and RANKL mediated osteoclastogenesis by fibroblast‐like synoviocytes in rheumatoid arthritis
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DOI: 10.1016/j.molimm.2017.09.003
Abstract: HighlightsIL‐17 regulates Cyr61, IL‐23 and GM‐CSF expression by AA‐FLS via STAT‐3 signaling.Knockdown of IL‐17RA or inhibition of STAT‐3 activation abrogated these effects.IL‐17 enhanced the expression of IL‐17RA and SHP‐2 in AA‐FLS.IL‐17/IL‐17RA/STAT‐3 signaling cascade is crucial… read more here.
Keywords: 17ra stat; cyr61 csf; fls; expression ... See more keywords