The Role of Chirality of [18F]SMBT-1 in Imaging of Monoamine Oxidase-B.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00655
Abstract: (S)-(2-Methylpyrid-5-yl)-6-[(3-[18F]fluoro-2-hydroxy)propoxy]quinoline ([18F]SMBT-1) was recently developed as a novel class of selective and reversible monoamine oxidase-B (MAO-B) tracers for in vivo imaging of reactive astrogliosis via positron emission tomography. To investigate the effect of the chirality… read more here.
Keywords: mao; chirality 18f; 18f smbt; 18f 18f ... See more keywords
Synthesis and preliminary evaluations of [18F]fluorinated pyridine-2-carboxamide derivatives for targeting PD-L1 in cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009623666221021121014
Abstract: BACKGROUND Treatment with immune checkpoint inhibitors has improved both progression-free survival and overall survival in a subset of patients with tumors. However, the selection of patients who benefit from immune checkpoint inhibitor treatment remains challenging.… read more here.
Keywords: 18f 18f; pyridine carboxamide; carboxamide derivatives; cancer ... See more keywords
Toward Novel [18F]Fluorine-Labeled Radiotracers for the Imaging of α-Synuclein Fibrils
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.830704
Abstract: The accumulation of α-synuclein aggregates (α-syn) in the human brain is an occurrence common to all α-synucleinopathies. Non-invasive detection of these aggregates in a living brain with a target-specific radiotracer is not yet possible. We… read more here.
Keywords: 18f 18f; synuclein; brain; binding affinity ... See more keywords
Radical C–H 18F-Difluoromethylation of Heteroarenes with [18F]Difluoromethyl Heteroaryl-Sulfones by Visible Light Photoredox Catalysis
Sign Up to like & getrecommendations! Published in 2020 at "Catalysts"
DOI: 10.3390/catal10030275
Abstract: The 18F-labeling of CF2H groups has been recently studied in radiopharmaceutical chemistry owing to the favorable nuclear and physical characteristics of the radioisotope 18F for positron emission tomography (PET). Following up on the reported efficiency… read more here.
Keywords: 18f difluoromethylation; 18f difluoromethyl; 18f 18f; difluoromethyl heteroaryl ... See more keywords