Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies
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DOI: 10.1007/s00259-024-06637-6
Abstract: We hypothesized that severe tau burden in brain regions involved in direct or indirect pathways of the basal ganglia correlate with more severe striatal dopamine deficiency in four-repeat (4R) tauopathies. Therefore, we correlated [18F]PI-2620 tau-positron-emission-tomography… read more here.
Keywords: dopamine deficiency; dat availability; 18f 2620; tau ... See more keywords
Exploring the origins of frequent tau-PET signal in vermal and adjacent regions
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DOI: 10.1007/s00259-025-07199-x
Abstract: Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent studies indicated a relevant binding of novel tau tracers to melanin-containing structures. To… read more here.
Keywords: pet signal; tau pet; 18f 2620; tau ... See more keywords
Clinical Evaluation of 18F-PI-2620 as a Potent PET Radiotracer Imaging Tau Protein in Alzheimer Disease and Other Neurodegenerative Diseases Compared With 18F-THK-5351
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DOI: 10.1097/rlu.0000000000003261
Abstract: Purpose PET is a useful tool for detecting the presence and extent of brain tau accumulation. However, most first-generation tau PET tracers are limited for high off-target binding and detection of tau in non-Alzheimer disease… read more here.
Keywords: 18f thk; 18f 2620; tau; alzheimer disease ... See more keywords
Multicenter 18F-PI-2620 PET for In Vivo Braak Staging of Tau Pathology in Alzheimer’s Disease
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DOI: 10.3390/biom12030458
Abstract: Tau aggregates accumulate in the Alzheimer’s disease (AD) brain according to the established Braak staging scheme and spread from transentorhinal over limbic regions to the neocortex. To impact the management of AD patients, an in… read more here.
Keywords: braak; tau; pet; 18f 2620 ... See more keywords