Regional vesicular acetylcholine transporter distribution in human brain: A [18F]fluoroethoxybenzovesamicol positron emission tomography study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24541
Abstract: Prior efforts to image cholinergic projections in human brain in vivo had significant technical limitations. We used the vesicular acetylcholine transporter (VAChT) ligand [18F]fluoroethoxybenzovesamicol ([18F]FEOBV) and positron emission tomography to determine the regional distribution of… read more here.
Keywords: distribution; 18f feobv; feobv binding; human brain ... See more keywords
Modeling of [18F]FEOBV Pharmacokinetics in Rat Brain
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DOI: 10.1007/s11307-019-01466-8
Abstract: Purpose[18F]Fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the vesicular acetylcholine transporter (VAChT), a marker of the cholinergic system. We evaluated the quantification of [18F]FEOBV in rats in control conditions and after partial saturation of VAChT using… read more here.
Keywords: vacht; reference tissue; 18f feobv; suv ... See more keywords
No Dopamine Agonist Modulation of Brain [18F]FEOBV Binding in Parkinson’s Disease
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DOI: 10.1021/acs.molpharmaceut.1c00961
Abstract: The [18F]fluoroethoxybenzovesamicol ([18F]FEOBV) positron emission tomography (PET) ligand targets the vesicular acetylcholine transporter. Recent [18F]FEOBV PET rodent studies suggest that regional brain [18F]FEOBV binding may be modulated by dopamine D2-like receptor agents. We examined associations… read more here.
Keywords: feobv; disease; brain 18f; feobv binding ... See more keywords
Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [18F]-FEOBV
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DOI: 10.1038/s41380-018-0130-5
Abstract: [18F]-fluoroethoxybenzovesamicol ([18F]-FEOBV) is a vesamicol analogue selectively binding the vesicular acetylcholine transporter (VAChT), a protein expressed uniquely by cholinergic neurons1. Non-invasive and short duration PET imaging acquisition protocols allowing accurate quantification of VAChT are preferred… read more here.
Keywords: pet imaging; brain cholinergic; quantification; quantification brain ... See more keywords
Mapping Cholinergic Synaptic Loss in Parkinson's Disease: An [18F]FEOBV PET Case-Control Study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Parkinson's disease"
DOI: 10.3233/jpd-223489
Abstract: BACKGROUND Cholinergic degeneration is strongly associated with cognitive decline in patients with Parkinson's disease (PD) but may also cause motor symptoms and olfactory dysfunction. Regional differences are striking and may reflect different PD related symptoms… read more here.
Keywords: degeneration; disease; parkinson disease; motor ... See more keywords