Repeatability of quantitative 18F-FLT uptake measurements in solid tumors: an individual patient data multi-center meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-017-3923-x
Abstract: Introduction3′-deoxy-3′-[18F]fluorothymidine (18F–FLT) positron emission tomography (PET) provides a non-invasive method to assess cellular proliferation and response to antitumor therapy. Quantitative 18F–FLT uptake metrics are being used for evaluation of proliferative response in investigational setting, however… read more here.
Keywords: multi center; repeatability; flt uptake; 18f flt ... See more keywords
In vivo imaging of cell proliferation in meningioma using 3′-deoxy-3′-[18F]fluorothymidine PET/MRI
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-04704-2
Abstract: Positron emission tomography (PET) with 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) provides a noninvasive assessment of tumour proliferation in vivo and could be a valuable imaging modality for assessing malignancy in meningiomas. We investigated a range of static and… read more here.
Keywords: pet; deoxy 18f; proliferation; 18f fluorothymidine ... See more keywords
PET Cell Tracking Using 18F-FLT is Not Limited by Local Reuptake of Free Radiotracer
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DOI: 10.1038/srep44233
Abstract: Assessing the retention of cell therapies following implantation is vital and often achieved by labelling cells with 2′-[18F]-fluoro-2′-deoxy-D-glucose (18F-FDG). However, this approach is limited by local retention of cell-effluxed radiotracer. Here, in a preclinical model… read more here.
Keywords: cell tracking; 18f flt; 18f fdg; cell ... See more keywords
In-vivo Comparison of 18F-FLT uptake, CT Number, Tumor Volume in Evaluation of Repopulation during Radiotherapy for Lung cancer
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DOI: 10.1038/srep46000
Abstract: Accelerated repopulation has been observed in various tumors. This study was aimed to evaluate the potential of 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) uptake and Computed Tomography Number (CTN) in monitoring tumor responses to radiotherapy compared with tumor volume… read more here.
Keywords: tumor volume; repopulation; flt uptake; 18f flt ... See more keywords
IMMU-19. PRECLINICAL THERAPEUTIC ACTIVITY AND PET IMAGING OF STING AGONIST 8803 IN GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0612
Abstract: STING (stimulator of interferon genes) activation triggers interferon (IFN) release within the tumor microenvironment from myeloid cells and other cell types, inducing proinflammatory anti-tumor immune responses. The small molecule STING agonist, 8803, elicits long-term survival… read more here.
Keywords: mice; glioblastoma; sting agonist; tumor ... See more keywords
Combining 3'-Deoxy-3'-[18F] fluorothymidine and MRI increases the sensitivity of glioma volume detection.
Sign Up to like & getrecommendations! Published in 2019 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001056
Abstract: OBJECTIVE 3'-Deoxy-3'-[18F] fluorothymidine (18F-FLT) is a marker of cell proliferation and displays a high tumor-to-background ratio in brain tumor lesions. We determined whether combining 18F-FLT PET and MRI study improves the detection of tumoral tissue… read more here.
Keywords: 18f fluorothymidine; 18f flt; glioma; mri ... See more keywords
Multiparametric prediction of pulmonary occupying lesion benignancy: combining 18F-fluorodeoxyglucose and 18F-fluorothymidine PET radiomics with metabolic and clinical features.
Sign Up to like & getrecommendations! Published in 2025 at "Nuclear medicine communications"
DOI: 10.1097/mnm.0000000000002072
Abstract: BACKGROUND This study evaluates the diagnostic value of PET/computed tomography imaging features using dual tracers, 18F-fluorodeoxyglucose (18F-FDG) and 18F-fluorothymidine (18F-FLT), combined with metabolic parameters and clinical characteristics, to differentiate benign and malignant pulmonary occupying lesions… read more here.
Keywords: 18f fluorothymidine; 18f fluorodeoxyglucose; fluorodeoxyglucose 18f; pet ... See more keywords
Quantitative Assessment of Bone Marrow Activity Using 18F-FLT PET in Aplastic Anemia and Myelodysplastic Syndromes
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DOI: 10.1097/rlu.0000000000004419
Abstract: Purpose Peripheral cytopenias are typical of blood test abnormalities associated with a variety of conditions, including aplastic anemia (AA) and myelodysplastic syndromes (MDSs). We prospectively investigated the feasibility of quantitative analysis of whole-body bone marrow… read more here.
Keywords: mds; bone marrow; 18f flt; flt pet ... See more keywords
Baseline and on Treatment Biodistribution Variability of 18F-FLT Uptake in Patients With Advanced Melanoma: Brief Communication
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000005281
Abstract: Purpose This prospective study evaluates the biodistribution of 18F-FLT PET in patients with advanced melanoma before and after treatment with BRAF/MEK inhibitors. Patients and Methods Eighteen BRAF-positive unresectable stage IIIc or IV melanoma patients referred… read more here.
Keywords: treatment; flt uptake; patients advanced; advanced melanoma ... See more keywords
Evaluation of the Therapeutic Response and Recurrence by 18F-FLT PET in a Case of Central Nervous System-Lymphomatoid Granulomatosis.
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DOI: 10.1097/rlu.0000000000005953
Abstract: A 78-year-old man visited our hospital complaining of cognitive decline and gait disturbance. MRI revealed multiple nodular enhancing lesions in the brain. He was pathologically diagnosed with central nervous system-lymphomatoid granulomatosis (CNS-LYG) by brain biopsy.… read more here.
Keywords: central nervous; flt pet; pet; recurrence ... See more keywords
Intratumoral 18F-FLT infusion in metabolic targeted radiotherapy
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DOI: 10.1186/s13550-019-0496-7
Abstract: BackgroundThe goal of targeted radiotherapy (TRT) is to administer radionuclides to tumor cells, while limiting radiation exposure to normal tissues. 3′-Deoxy-3′-[18F]-fluorothymidine (18F-FLT) is able to target tumor cells and emits a positron with energy appropriate… read more here.
Keywords: targeted radiotherapy; administration; infusion; 18f flt ... See more keywords