Repeatability of quantitative 18F-FLT uptake measurements in solid tumors: an individual patient data multi-center meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-017-3923-x
Abstract: Introduction3′-deoxy-3′-[18F]fluorothymidine (18F–FLT) positron emission tomography (PET) provides a non-invasive method to assess cellular proliferation and response to antitumor therapy. Quantitative 18F–FLT uptake metrics are being used for evaluation of proliferative response in investigational setting, however… read more here.
Keywords: multi center; repeatability; flt uptake; 18f flt ... See more keywords
In vivo imaging of cell proliferation in meningioma using 3′-deoxy-3′-[18F]fluorothymidine PET/MRI
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DOI: 10.1007/s00259-020-04704-2
Abstract: Positron emission tomography (PET) with 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) provides a noninvasive assessment of tumour proliferation in vivo and could be a valuable imaging modality for assessing malignancy in meningiomas. We investigated a range of static and… read more here.
Keywords: pet; deoxy 18f; proliferation; 18f fluorothymidine ... See more keywords
PET Cell Tracking Using 18F-FLT is Not Limited by Local Reuptake of Free Radiotracer
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DOI: 10.1038/srep44233
Abstract: Assessing the retention of cell therapies following implantation is vital and often achieved by labelling cells with 2′-[18F]-fluoro-2′-deoxy-D-glucose (18F-FDG). However, this approach is limited by local retention of cell-effluxed radiotracer. Here, in a preclinical model… read more here.
Keywords: cell tracking; 18f flt; 18f fdg; cell ... See more keywords
In-vivo Comparison of 18F-FLT uptake, CT Number, Tumor Volume in Evaluation of Repopulation during Radiotherapy for Lung cancer
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DOI: 10.1038/srep46000
Abstract: Accelerated repopulation has been observed in various tumors. This study was aimed to evaluate the potential of 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) uptake and Computed Tomography Number (CTN) in monitoring tumor responses to radiotherapy compared with tumor volume… read more here.
Keywords: tumor volume; repopulation; flt uptake; 18f flt ... See more keywords
Combining 3'-Deoxy-3'-[18F] fluorothymidine and MRI increases the sensitivity of glioma volume detection.
Sign Up to like & getrecommendations! Published in 2019 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001056
Abstract: OBJECTIVE 3'-Deoxy-3'-[18F] fluorothymidine (18F-FLT) is a marker of cell proliferation and displays a high tumor-to-background ratio in brain tumor lesions. We determined whether combining 18F-FLT PET and MRI study improves the detection of tumoral tissue… read more here.
Keywords: 18f fluorothymidine; 18f flt; glioma; mri ... See more keywords
Quantitative Assessment of Bone Marrow Activity Using 18F-FLT PET in Aplastic Anemia and Myelodysplastic Syndromes
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DOI: 10.1097/rlu.0000000000004419
Abstract: Purpose Peripheral cytopenias are typical of blood test abnormalities associated with a variety of conditions, including aplastic anemia (AA) and myelodysplastic syndromes (MDSs). We prospectively investigated the feasibility of quantitative analysis of whole-body bone marrow… read more here.
Keywords: mds; bone marrow; 18f flt; flt pet ... See more keywords
Intratumoral 18F-FLT infusion in metabolic targeted radiotherapy
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DOI: 10.1186/s13550-019-0496-7
Abstract: BackgroundThe goal of targeted radiotherapy (TRT) is to administer radionuclides to tumor cells, while limiting radiation exposure to normal tissues. 3′-Deoxy-3′-[18F]-fluorothymidine (18F-FLT) is able to target tumor cells and emits a positron with energy appropriate… read more here.
Keywords: targeted radiotherapy; administration; infusion; 18f flt ... See more keywords
[18F]FDG and [18F]FLT PET for the evaluation of response to neo-adjuvant chemotherapy in a model of triple negative breast cancer
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DOI: 10.1371/journal.pone.0197754
Abstract: Rationale Pathological response to neo-adjuvant chemotherapy (NAC) represents a commonly used predictor of survival in triple negative breast cancer (TNBC) and the need to identify markers that predict response to NAC is constantly increasing. Aim… read more here.
Keywords: response; evaluation; 18f flt; 18f fdg ... See more keywords
Dual-Tracer Assessment of Dynamic Changes in Reoxygenation and Proliferation Decrease During Fractionated Radiotherapy in Murine Tumors
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DOI: 10.3389/fonc.2020.01046
Abstract: Objective: The present work aimed to assess reoxygenation and tumor inhibition during fractionated radiotherapy (FRT) in murine tumors using 18F-fluoromisonidazole (18F-FMISO) and 18F-fluorothymidine (18F-FLT) based micro positron emission tomography/computed tomography (PET/CT). Materials and Methods: A… read more here.
Keywords: inter frt; pet; frt; 18f fmiso ... See more keywords
Exploratory Analysis of 18F-3’-deoxy-3’-fluorothymidine (18F-FLT) PET/CT-Based Radiomics for the Early Evaluation of Response to Neoadjuvant Chemotherapy in Patients With Locally Advanced Breast Cancer
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DOI: 10.3389/fonc.2021.601053
Abstract: Purpose The objective of this study was to evaluate a set of radiomics-based advanced textural features extracted from 18F-FLT-PET/CT images to predict tumor response to neoadjuvant chemotherapy (NCT) in patients with locally advanced breast cancer… read more here.
Keywords: flt pet; pet; response; 18f flt ... See more keywords
Molecular Imaging with 3′-deoxy-3′[(18)F]-Fluorothymidine (18F-FLT) PET/CT for Early Response to Targeted Therapies in Sarcomas: A Pilot Study
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DOI: 10.3390/diagnostics10030125
Abstract: Although 3′-deoxy-3′[(18)F]-fluorothymidine (FLT)-positron emission tomography (PET) has been utilized for tumor response assessment to neoadjuvant chemotherapy in soft tissue sarcomas, it has not been exploited for the assessment of early response to systematically targeted therapies.… read more here.
Keywords: early response; flt pet; 18f flt; targeted therapies ... See more keywords