Is there a difference in regional read [18F]flutemetamol amyloid patterns between end-of-life subjects and those with amnestic mild cognitive impairment?
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04282-y
Abstract: PurposeVisual interpretation of PET [18F]flutemetamol images relies on systematic review of five brain regions and is considered positive when an elevated signal is observed in at least one region. Amnestic mild cognitive impairment (aMCI) is… read more here.
Keywords: amnestic mild; amyloid; amci patients; 18f flutemetamol ... See more keywords
Parametric imaging of dual-time window [18F]flutemetamol and [18F]florbetaben studies
Sign Up to like & getrecommendations! Published in 2021 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2021.117953
Abstract: Optimal pharmacokinetic models for quantifying amyloid beta (Aβ) burden using both [18F]flutemetamol and [18F]florbetaben scans have previously been identified at a region of interest (ROI) level. The purpose of this study was to determine optimal… read more here.
Keywords: time window; 18f florbetaben; 18f flutemetamol; flutemetamol 18f ... See more keywords
Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer’s disease with PET imaging agents 18F-flutemetamol and 18F-florbetaben
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DOI: 10.1186/s12868-018-0447-7
Abstract: BackgroundAlthough amyloid beta (Aβ) imaging is widely used for diagnosing and monitoring Alzheimer’s disease in clinical fields, paralleling comparison between 18F-flutemetamol and 18F-florbetaben was rarely attempted in AD mouse model. We performed a comparison of… read more here.
Keywords: 18f flutemetamol; flutemetamol 18f; flutemetamol images; 18f florbetaben ... See more keywords
Temporal and anatomical distribution of 18F-flutemetamol uptake in canine brain using positron emission tomography
Sign Up to like & getrecommendations! Published in 2020 at "BMC Veterinary Research"
DOI: 10.1186/s12917-020-2240-y
Abstract: Background Positron emission tomography (PET) is increasingly being used as an imaging modality for clinical and research applications in veterinary medicine. Amyloid PET has become a useful tool for diagnosing Alzheimer’s disease (AD) in humans,… read more here.
Keywords: 18f flutemetamol; positron emission; injection; emission tomography ... See more keywords
Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000006875
Abstract: Objective To examine the cross-sectional associations between regional tau, β-amyloid (Aβ), and cortical thickness and neuropsychological function across the preclinical and clinical spectrum of Alzheimer disease (AD). Methods We included 106 participants from the Swedish… read more here.
Keywords: cortical thickness; 18f flutemetamol; alzheimer disease; thickness ... See more keywords
Evaluation of semi-quantitative measures of 18F-flutemetamol PET for the clinical diagnosis of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Quantitative imaging in medicine and surgery"
DOI: 10.21037/qims-21-188
Abstract: Background 18F-flutemetamol positron emission tomography (PET) is used to assess cortical amyloid-β burden in patients with cognitive impairment to support a clinical diagnosis. Visual classification is the most widely used method in clinical practice although… read more here.
Keywords: quantitative measures; semi quantitative; clinical diagnosis; disease ... See more keywords
Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.118.211532
Abstract: Our objective was to determine the optimal approach for assessing amyloid disease in a cognitively normal elderly population. Methods: Dynamic 18F-flutemetamol PET scans were acquired using a coffee-break protocol (a 0- to 30-min scan and… read more here.
Keywords: bpnd; cognitively normal; pathology; 18f flutemetamol ... See more keywords
High-Resolution Silicon Photomultiplier Time-of-Flight Dedicated Head PET System for Clinical Brain Studies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.122.264080
Abstract: Visual Abstract We acquired brain 18F-FDG and 18F-flutemetamol PET images using a time-of-flight system dedicated to the head (dhPET) and a conventional whole-body PET/CT (wbPET) system and evaluated the clinical superiority of dhPET over wbPET.… read more here.
Keywords: wbpet; 18f flutemetamol; pet; dhpet ... See more keywords
Cerebellar and Cerebral Amyloid Visualized by [18F]flutemetamol PET in Long-Term Hereditary V30M (p.V50M) Transthyretin Amyloidosis Survivors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.816636
Abstract: Introduction Hereditary transthyretin (ATTRv) amyloidosis caused by the V30M (p. V50M) mutation is a fatal, neuropathic systemic amyloidosis. Liver transplantation has prolonged the survival of patients and central nervous system (CNS) complications, attributed to amyloid… read more here.
Keywords: long term; transthyretin; 18f flutemetamol; amyloidosis survivors ... See more keywords