Isotope Exchange-Based 18F-Labeling Methods.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00530
Abstract: 18F-Labeling methods for the preparation of 18F-labeled molecular probes can be classified into electrophilic fluorination, nucleophilic fluorination, metal-F coordination, and 18F/19F isotope exchange. Isotope exchange-based 18F-labeling methods demonstrate mild conditions featuring water resistance and facile… read more here.
Keywords: labeling methods; exchange based; based 18f; isotope exchange ... See more keywords
Direct 18F-Labeling of Biomolecules via Spontaneous Site-Specific Nucleophilic Substitution by F- on Phosphonate Prostheses.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01211
Abstract: We describe a high radiochemical yield late-stage direct 18F-labeling of bare biomolecules containing common active groups. Spontaneity and site-selectivity are attributed to the remarkably higher rates of nucleophilic substitution reactions on phosphonates than on other… read more here.
Keywords: nucleophilic substitution; 18f labeling; direct 18f; labeling biomolecules ... See more keywords
An Organometallic Gold(III) Reagent for 18F Labeling of Unprotected Peptides and Sugars in Aqueous Media.
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DOI: 10.1021/acs.orglett.2c01965
Abstract: The 18F labeling of unprotected peptides and sugars with a Au(III)-[18F]fluoroaryl complex is reported. The chemoselective method generates 18F-labeled S-aryl bioconjugates in an aqueous environment in 15 min with high radiochemical yields and displays excellent… read more here.
Keywords: 18f labeling; iii; peptides sugars; labeling unprotected ... See more keywords
Optimization of Direct Aromatic 18F-Labeling of Tetrazines
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DOI: 10.3390/molecules27134022
Abstract: Radiolabeling of tetrazines has gained increasing attention due to their important role in pretargeted imaging or therapy. The most commonly used radionuclide in PET imaging is fluorine-18. For this reason, we have recently developed a… read more here.
Keywords: direct aromatic; rcy; aromatic 18f; optimization direct ... See more keywords
Simplified one-pot 18F-labeling of biomolecules with in situ generated fluorothiophosphate synthons in high molar activity
Sign Up to like & getrecommendations! Published in 2023 at "Theranostics"
DOI: 10.7150/thno.79452
Abstract: Rationale: Conventional 18F-labeling methods that demand substrate pre-modification or lengthy radiosynthesis procedures have impeded the visualization and translation of numerous biomolecules, as biomarkers or ligands, using modern positron emission tomography techniques in vivo. Moreover, 18F-labeled… read more here.
Keywords: ftp synthons; 18f labeled; high molar; molar activity ... See more keywords