Relationship Between Reactive Astrocytes, by [18F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer’s Disease
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DOI: 10.1007/s12035-024-04106-7
Abstract: Reactive astrocytes play an important role in the development of Alzheimer’s disease (AD). Here, we aimed to investigate the temporospatial relationships among monoamine oxidase-B, tau and amyloid-β (Aβ), translocator protein, and glucose metabolism by using… read more here.
Keywords: mice; app ps1; old app; month old ... See more keywords
The Role of Chirality of [18F]SMBT-1 in Imaging of Monoamine Oxidase-B.
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DOI: 10.1021/acschemneuro.1c00655
Abstract: (S)-(2-Methylpyrid-5-yl)-6-[(3-[18F]fluoro-2-hydroxy)propoxy]quinoline ([18F]SMBT-1) was recently developed as a novel class of selective and reversible monoamine oxidase-B (MAO-B) tracers for in vivo imaging of reactive astrogliosis via positron emission tomography. To investigate the effect of the chirality… read more here.
Keywords: mao; chirality 18f; 18f smbt; 18f 18f ... See more keywords
Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-220908
Abstract: Background: Astrocyte reactivity is an early event along the Alzheimer’s disease (AD) continuum. Plasma glial fibrillary acidic protein (GFAP), posited to reflect astrocyte reactivity, is elevated across the AD continuum from preclinical to dementia stages.… read more here.
Keywords: associated 18f; smbt pet; 18f smbt; plasma ... See more keywords