Gray matter structural networks related to 18F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients
Sign Up to like & getrecommendations! Published in 2021 at "eNeurologicalSci"
DOI: 10.1016/j.ensci.2021.100309
Abstract: Objective This study aimed to examine the alterations in gray matter networks related to tau retention in Alzheimer's disease (AD) patients and cognitively normal (CN) older individuals. Methods Eighteen amyloid-positive AD patients and 30 age-… read more here.
Keywords: network; 18f thk5351; network properties; local network ... See more keywords
18F-THK5351 PET imaging in patients with progressive supranuclear palsy: associations with core domains and diagnostic certainty
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-76339-0
Abstract: The associations of 18F-THK5351 tau positron emission tomography (PET) findings with core domains of progressive supranuclear palsy (PSP) and its diagnostic certainty have yet to be fully elucidated. The 18F-THK5351 PET patterns of 17 patients… read more here.
Keywords: 18f thk5351; thk5351 pet; core domains; progressive supranuclear ... See more keywords
Distribution Pattern of the Monoamine Oxidase B Ligand, 18F-THK5351, in the Healthy Brain
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000004272
Abstract: Background 18F-THK5351 PET estimates the concentrations of monoamine oxidase B (MAO-B) that are preferentially located in astrocytes and can be used to visualize and quantify ongoing astrogliosis. To study images of astrogliosis in neurological disorders,… read more here.
Keywords: distribution pattern; 18f thk5351; thk5351; thk5351 healthy ... See more keywords
Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18F-THK5351.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000004425
Abstract: ABSTRACT The Alzheimer disease (AD) brain is characterized microscopically by the presence of extracellular amyloid plaques and intraneuronal neurofibrillary tangles consisting of phosphorylated tau aggregations. 18F-THK5351 is a first-generation PET tau tracer that also binds… read more here.
Keywords: stereotactic surface; 18f thk5351; surface projection; dimensional stereotactic ... See more keywords
18F-THK5351 PET Can Evaluate Tumor Extension in Intravascular Large B-Cell Lymphoma: Comparison With 11C-Methionine PET and 18F-FDG PET.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000004568
Abstract: ABSTRACT A 79-year-old man presenting with gait disturbance and cognitive decline was diagnosed with intravascular large B-cell lymphoma (IVLBCL) by random skin biopsy. Some IVLBCL lesions were identified by PET examinations using 11C-methionine, 18F-FDG, and… read more here.
Keywords: 18f thk5351; 11c methionine; pet; pet 18f ... See more keywords
Early brainstem [18F]THK5351 uptake is linked to cortical hyperexcitability in healthy aging
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.142514
Abstract: BACKGROUND Neuronal hyperexcitability characterizes the early stages of Alzheimer’s disease (AD). In animals, early misfolded tau and amyloid-β (Aβ) protein accumulation — both central to AD neuropathology — promote cortical excitability and neuronal network dysfunction.… read more here.
Keywords: 18f thk5351; cortical excitability; excitability; brainstem ... See more keywords
Voxel-based correlation of 18F-THK5351 accumulation and gray matter volume in the brain of cognitively normal older adults
Sign Up to like & getrecommendations! Published in 2019 at "EJNMMI Research"
DOI: 10.1186/s13550-019-0552-3
Abstract: BackgroundsAlthough neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) volume in cognitively normal older adults.… read more here.
Keywords: accumulation; volume; 18f thk5351; cognitively normal ... See more keywords
[18F]-THK5351 PET Correlates with Topology and Symptom Severity in Progressive Supranuclear Palsy
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2017.00440
Abstract: Progressive supranuclear palsy (PSP) is a neurodegenerative movement disorder characterized by deposition of fibrillar aggregates of 4R tau-protein in neurons and glial cells of the brain. These deposits are a key neuropathological finding, allowing a… read more here.
Keywords: 18f thk5351; psp; topology; severity ... See more keywords