18F-Trifluoromethanesulfinate Enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides
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DOI: 10.1021/jacs.9b11709
Abstract: 18F labeling strategies for unmodified peptides with [18F]fluoride require 18F-labeled prosthetics for bioconjugation more often with cysteine thiols or lysine amines. Here we explore selective radical chemistry to target aromatic residues applying C–H 18F-trifluoromethylation. We… read more here.
Keywords: aromatic residues; direct 18f; peptides 18f; 18f trifluoromethanesulfinate ... See more keywords
Advances in [18F]Trifluoromethylation Chemistry for PET Imaging
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DOI: 10.3390/molecules26216478
Abstract: Positron emission tomography (PET) is a preclinical and clinical imaging technique extensively used to study and visualize biological and physiological processes in vivo. Fluorine-18 (18F) is the most frequently used positron emitter for PET imaging… read more here.
Keywords: trifluoromethylation chemistry; pet imaging; chemistry; 18f trifluoromethylation ... See more keywords