Comparison of 1p and 19q status of glioblastoma by whole exome sequencing, array-comparative genomic hybridization, and fluorescence in situ hybridization
Sign Up to like & getrecommendations! Published in 2018 at "Medical Oncology"
DOI: 10.1007/s12032-018-1119-2
Abstract: According to the 2016 World Health Organization classification of tumors of the central nervous system, detecting 1p/19q co-deletion became essential in clinical neuropathology for gliomas with oligodendroglioma-like morphology. Here, we assessed genomic profiles of glioblastoma… read more here.
Keywords: hybridization; 19q deletion; deletion; situ hybridization ... See more keywords
ATRX immunohistochemistry can help refine ‘not elsewhere classified’ categorisation for grade II/III gliomas
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DOI: 10.1080/02688697.2019.1600657
Abstract: Abstract Purpose: The 2016 WHO tumour classification highlights the role of IDH1/2 gene mutation and 1p/19q co-deletion in classifying grade II/III gliomas. A recent cIMPACT-NOW update proposes the use of the term ‘Not Elsewhere Classified’… read more here.
Keywords: immunohistochemistry; gliomas; atrx; 19q deletion ... See more keywords
Abstract 743: An amplicon sequencing based all-in-one genetic testing panel for molecular classification and guiding individualized treatment of brain cancer
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DOI: 10.1158/1538-7445.am2020-743
Abstract: Background: Incorporation of molecular biomarkers and histological features could be applicated for more-precise tumour categorization and individualized treatment. IDH1/2 mutations, 1p/19q co-deletion and TERT-promoter mutations were requisite diagnostic biomarkers for gliomas classification. BRAF V600E mutation… read more here.
Keywords: 19q deletion; deletion; biomarkers panel; cancer ... See more keywords
Thin-Slice Magnetic Resonance Imaging-Based Radiomics Signature Predicts Chromosomal 1p/19q Co-deletion Status in Grade II and III Gliomas
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DOI: 10.3389/fneur.2020.551771
Abstract: Objective: Chromosomal 1p/19q co-deletion is recognized as a diagnostic, prognostic, and predictive biomarker in lower grade glioma (LGG). This study aims to construct a radiomics signature to non-invasively predict the 1p/19q co-deletion status in LGG.… read more here.
Keywords: 19q deletion; radiomics signature; deletion status; signature ... See more keywords