The 19S proteasome subunit Rpt5 reversibly associates with cold‐stable microtubules in glial cells at low temperatures
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14307
Abstract: The ubiquitin–proteasome system (UPS) degrades intracellular proteins through the 26S proteasome. We analysed how cold stress affects the UPS in glial cells. Together with a reduction in the 20S proteolytic activity and increased levels of… read more here.
Keywords: stable microtubules; 19s proteasome; subunit; glial cells ... See more keywords
Depleting the 19S proteasome regulatory PSMD1 subunit as a cancer therapy strategy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5775
Abstract: Proteasome inhibitors are in use in treating certain types of cancers. These drugs inhibit the catalytic activity of the 20S proteasome, shared by all the different proteasome complexes. Inhibitors of the 26S‐associated deubiquitinating activity explicitly… read more here.
Keywords: proteasome regulatory; depleting 19s; 19s proteasome; strategy ... See more keywords
The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast
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DOI: 10.1007/s00294-017-0792-6
Abstract: Accumulating evidence shows that non-proteolytic functions of the proteasome are as crucial as its well-known proteolytic function in regulating cellular activities. In our recent work, we showed that the 19S proteasome mediates the heterochromatin spreading… read more here.
Keywords: heterochromatin; 19s proteasome; subtelomere silencing; silencing facultative ... See more keywords
Deregulation of the 19S proteasome complex increases yeast resistance to 4‐NQO and oxidative stress via upregulation of Rpn4‐ and proteasome‐dependent stress responsive genes
Sign Up to like & getrecommendations! Published in 2019 at "FEMS Yeast Research"
DOI: 10.1093/femsyr/foz002
Abstract: Abstract The 26S proteasome participates in cell stress responses via its ability to degrade regulatory and damaged proteins. In yeast, mutations in the subunits of the 19S proteasome regulatory subcomplex cause hyper‐resistance to 4‐nitroquinoline‐1‐oxide (4‐NQO),… read more here.
Keywords: 19s proteasome; proteasome complex; resistance nqo; stress ... See more keywords
19S Proteasome Subunits as Oncogenes and Prognostic Biomarkers in FLT3-Mutated Acute Myeloid Leukemia (AML)
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DOI: 10.3390/ijms232314586
Abstract: 26S proteasome non-ATPase subunits 1 (PSMD1) and 3 (PSMD3) were recently identified as prognostic biomarkers and potential therapeutic targets in chronic myeloid leukemia (CML) and multiple solid tumors. In the present study, we analyzed the… read more here.
Keywords: myeloid leukemia; prognostic biomarkers; proteasome subunits; 19s proteasome ... See more keywords