Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity ‐ The hyperbilirubinemia use case
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DOI: 10.1016/j.ejps.2017.01.002
Abstract: &NA; Hyperbilirubinemia is a pathological condition of excessive accumulation of conjugated or unconjugated bilirubin in blood. It has been associated with neurotoxicity and non‐neural organ dysfunctions, while it can also be a warning of liver… read more here.
Keywords: anion transporting; 1b1 1b3; hyperbilirubinemia; oatp1b1 oatp1b3 ... See more keywords
The pharmacokinetics of oral trazpiroben (TAK‐906) after organic anion transporting polypeptide 1B1/1B3 inhibition: A phase I, randomized study
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DOI: 10.1111/cts.13274
Abstract: Trazpiroben is a dopamine D2/D3 receptor antagonist under development for the treatment of gastroparesis. This phase I, open‐label, randomized, two‐way crossover study (NCT04121078) evaluated the effect of single‐dose intravenous rifampin, a potent inhibitor of the… read more here.
Keywords: inhibition; 1b1 1b3; organic anion; trazpiroben ... See more keywords