An iterative strategy to design 4-1BB agonist nanobodies de novo with generative AI models
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DOI: 10.1038/s41598-025-10241-5
Abstract: The 4-1BB receptor, a key member of the tumor necrosis factor receptor (TNFR) family, represents a highly promising target for cancer immunotherapy. In this study, we developed a novel in silico pipeline to design VHH… read more here.
Keywords: design 1bb; 1bb agonist; iterative strategy; agonist nanobodies ... See more keywords
IgG2a-formatted 4-1BB agonism combined with S100A9 inhibition enhances T cell activation and tumor control in a preclinical model of multiple myeloma
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DOI: 10.1182/blood-2025-5696
Abstract: Introduction Immunotherapy has shown clinical promise in multiple myeloma (MM), but relapse remains common, largely due to the immunosuppressive bone marrow (BM) microenvironment, characterized by T cell exhaustion and the accumulation of myeloid-derived suppressor cells… read more here.
Keywords: formatted 1bb; preclinical model; tumor; 1bb agonist ... See more keywords