Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis.
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DOI: 10.1016/j.bone.2018.06.020
Abstract: Osteoarthritis is a joint disease characterized by cartilage degradation, altered gene expression and inflammation. NOTCH1 and NOTCH2 receptors and the JAGGED1 ligand regulate chondrocyte biology; however, the contribution of Notch signaling to osteoarthritis is controversial.… read more here.
Keywords: osteoarthritis; cheney syndrome; hajdu cheney; 1ecan mutants ... See more keywords