DL‐PDT for AK: multicentre trial comparing BF‐200 ALA with MAL
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DOI: 10.1111/bjd.18181
Abstract: Actinic keratoses (AK) are areas of sun‐damaged skin found mainly on parts of the body which have received lots of sun exposure. At first, they can be hard to see, and are more easily felt,… read more here.
Keywords: trial comparing; pdt multicentre; ala mal; 200 ala ... See more keywords
光化性角化病日光光动力疗法:对比 BF‐200 ALA 与 MAL 的多中心试验
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DOI: 10.1111/bjd.18191
Abstract: 光化性角化病(AK)是被阳光晒伤的皮肤区域,多见于受到阳光暴晒的身体部位。起初很难看到病灶,但能够感觉到皮肤变硬,就像砂纸一样。病灶直径可能增至1~2厘米。高达20%的AK可能会在10~25年内发展成一种名为鳞状细胞癌(SCC)的皮肤癌。该病症的一种治疗方法为日光光动力疗法(DL‐PDT),需要在病灶(受影响的皮肤区域)上涂敷含有“感光剂”的乳膏。感光剂本身是非活性的。但是当特定波长的光线照射在涂有感光剂的皮肤上时,感光剂会被激活,这种治疗可杀灭皮肤中的异常细胞。本研究的目的在于对比两种感光剂BF‐200 ALA与MAL的疗效(药物的功效)、耐受性(包括疼痛和副作用)及成本效益。总共69名患者(合计767个AK病灶对称分布在脸部或头皮)在芬兰的三个中心接受治疗。以随机脸部分开的设计形式(即,一半脸用一种感光剂治疗,另一半脸用另一种治疗)进行一段时间的DL‐PDT治疗。设盲观察者在治疗后12个月评估结果,他们不知道每侧脸采用哪种治疗。作者发现,BF‐200 ALA清除的AK病灶数显著多于MAL (79.7% vs 73.5%)。在对比同一患者的两半脸时,BF‐200 ALA治疗侧的AK清除率显著优于MAL治疗侧。接受两种感光剂治疗的患者在光治疗过程中报告的疼痛都很少,两者之间无显著差异。在DL‐PDT治疗后一周与治疗相关的皮肤反应在BF‐200 ALA治疗侧更强烈。在使用两种感光剂治疗的>90%病例中12个月的美容效果(外观效果)极好或很好。两种感光剂的DL‐PDT治疗成本类似,但BF‐200 ALA的疗效稍高。作者的结论是,在轻度和中度AK的DL‐PDT治疗中,BF‐200 ALA较MAL更有效,且性价比略胜一筹。 read more here.
Keywords: mal 200; ala mal; ala; 200 ala ... See more keywords
Day light photodynamic therapy with BF‐200 ALA: A case series
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DOI: 10.1111/dth.12666
Abstract: Dear Editor, Lesions of actinic keratosis (AK) are markers of photodamaged skin and constitute one of the most frequent reasons for the consultation of a dermatologist. Some authors defined them as precancerous lesions, while others… read more here.
Keywords: treatment; pdt; 200 ala; photodynamic therapy ... See more keywords
A review of BF-200 ALA for the photodynamic treatment of mild-to-moderate actinic keratosis.
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DOI: 10.2217/fon-2017-0247
Abstract: BF-200 ALA is a combination of a nanoscale-lipid vesicle formulation and the prodrug 5-aminolevulinic acid (5-ALA). The nanoemulsion stabilizes the prodrug and enhances its penetration through the stratum corneum. It has shown excellent therapeutic results… read more here.
Keywords: 200 ala; field; treatment; review 200 ... See more keywords