Computational analysis of the effect of polymerase acidic (PA) gene mutation F35L in the 2009 pandemic influenza A (H1N1) virus on binding aspects of mononucleotides in the endonuclease domain
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DOI: 10.1007/s00705-017-3681-x
Abstract: An F35L mutation in the N-terminal domain of the polymerase acidic protein (PA-Nter), which contains the active site of the endonuclease, has been reported to result in higher polymerase activity in mouse-adapted strains of the… read more here.
Keywords: polymerase acidic; influenza h1n1; pandemic influenza; polymerase ... See more keywords
Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus
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DOI: 10.3390/v11020116
Abstract: Influenza viruses are a threat to global public health resulting in ~500,000 deaths each year. Despite an intensive vaccination program, influenza infections remain a recurrent, yet unsolved public health problem. Secondary bacterial infections frequently complicate… read more here.
Keywords: staphylococcus aureus; infection; influenza; methicillin resistant ... See more keywords
Pandemic Influenza Vaccines: What did We Learn from the 2009 Pandemic and are We Better Prepared Now?
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DOI: 10.3390/vaccines8020211
Abstract: In 2009, a novel A(H1N1) influenza virus emerged with rapid human-to-human spread and caused the first pandemic of the 21st century. Although this pandemic was considered mild compared to the previous pandemics of the 20th… read more here.
Keywords: learn 2009; influenza vaccines; pandemic influenza; vaccines learn ... See more keywords