3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt.
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DOI: 10.1016/j.leukres.2017.08.007
Abstract: Acute lymphoblastic leukemia (ALL) samples exhibit an activated PI3K/Akt pathway, which suggests a general role of Akt in the development of leukemia. We have previously used western blot analysis to show that the catalytic topoisomerase… read more here.
Keywords: 3ez 20ac; apoptosis; activation atr; cyclin ... See more keywords