Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.09.051
Abstract: Background Effective targeting therapies for common chronic liver disease nonalcoholic steatohepatitis (NASH) are in urgent need. MicroRNA-targeted therapeutics would be potentially an effective treatment strategy of hepatic diseases. Here we investigated the functional role of… read more here.
Keywords: hepatic mir; mir 221; steatohepatitis; 221 222 ... See more keywords
MicroRNA 221/222 cluster kicks out Timp-3 to inflame the liver
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.10.040
Abstract: Non-alcoholic fatty liver disease (NAFLD), and its subtype nonof NASH while forcing its expression restrains hepatic inflammation, alcoholic steatohepatitis (NASH), prevalence is increasing worldwide leading to major complications such as cirrhosis and hepatocellular carcinoma (HCC)… read more here.
Keywords: microrna 221; mir 221; 221 222; 222 cluster ... See more keywords
MiR-221/222 inhibit insulin production of pancreatic β-cells in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology"
DOI: 10.1210/endocr/bqz027
Abstract: MicroRNAs are essential for the regulation of development, proliferation and functions of pancreatic β-cells. The conserved miR-221/222 cluster is an important regulator in multiple cellular processes. Here we investigated the functional role of miR-221/222 in… read more here.
Keywords: mir 221; proliferation; 221 222; insulin production ... See more keywords
Upregulated exosomal miR-221/222 promotes cervical cancer via repressing methyl-CpG-binding domain protein 2.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201905_17788
Abstract: OBJECTIVE Methyl-CpG-binding domain protein 2, a target gene of miR-221and miR-222, plays a crucial role in a large body of human cancers. In this study, we aim to explore the mechanism by which miR-221/222 promotes… read more here.
Keywords: mir 221; cervical cancer; hela caski; 221 222 ... See more keywords
Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00056
Abstract: microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the pathological initiation and progression of many human diseases. miR-221 and… read more here.
Keywords: potential value; diagnostic prognostic; value mir; mir 221 ... See more keywords
Genistein Promotes Skeletal Muscle Regeneration by Regulating miR-221/222
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113482
Abstract: Genistein (GEN), a phytoestrogen, has been reported to regulate skeletal muscle endocrine factor expression and muscle fiber type switching, but its role in skeletal muscle regeneration is poorly understood. As a class of epigenetic regulators… read more here.
Keywords: muscle; mir 221; muscle regeneration; skeletal muscle ... See more keywords