Therapeutic Targeting of P53: A Comparative Analysis of APR-246 and COTI-2 in Human Tumor Primary Culture 3-D Explants
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14030747
Abstract: Background: TP53 is the most commonly mutated gene in human cancer with loss of function mutations largely concentrated in “hotspots” affecting DNA binding. APR-246 and COTI-2 are small molecules under investigation in P53 mutated cancers.… read more here.
Keywords: apr 246; activity; p53; 246 coti ... See more keywords